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Evaluation of Multimodal Imaging Biomarkers of Prostate Cancer
Technical Report,01 Sep 2014,31 Aug 2015
Vanderbilt University Nashville United States
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The goals of the proposed studies are to i use imaging methods to non-invasively assess the temporal relationship between castration resistant prostate cancer CRPC growth, androgen receptor AR levels, angiogenesis, hypoxia, and translocator protein TSPO levels and ii use imaging to temporally direct pathological examination of tissue in order to enhance the elucidation of mechanistic aspects of CRPC progression, specifically the involvement of HIF-1alpha and NF-kappaB, two pathways that increase AR activity during progression to CRPC. During this year of the award focused on characterizing molecular imaging agents in the Pten p53 double null mutant mouse model. Towards that end, we have successfully acquired anatomic MRI and PET data in orthotopic tumors within the Ptenp53 mouse model, to assess tumor volume, track growth and tumor angiogenesis. We have further characterized the use of FMISO and TSPO imaging to evaluate tumor hypoxia and translocator protein expression. The characterization of these imaging features has found the exciting result that the uptake of a TSPO imaging agent developed in-house shows marked and very specific uptake in all the tumors we observed with MRI.
APPROVED FOR PUBLIC RELEASE