Regulation of Polysaccharide- and Protein- Specific Antibody Responses to Intact Extracellular Bacteria
Uniformed Services University of the Health Sciences Bethesda United States
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Many studies have been published detailing the mechanisms of antibody production in response to bacterial polysaccharides PS and proteins, either in soluble, isolated form andor as conjugate vaccines composed of an immunogenic carrier protein covalently linked to PS. However, much less is knownregarding antibody responses to PS and protein expressed naturally by intact extracellular bacteria. We describe two major projects in mice that investigated the mechanism of PS- andor protein-specific anti-IgG responses to intact, heat-killed Gram-positive andor Gram-negative bacteria, in comparison to PS- andor protein-specific IgG responses elicited by isolated PS or protein, andor conjugate vaccine.
- Medicine and Medical Research