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Evaluation of a Physiologically Based Pharmacokinetic (PBPK) Model Used to Develop Health Protective Levels for Trichloroethylene
Technical Report,01 Apr 2015,01 Sep 2016
HJF Wright-Patterson AFB United States
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Trichloroethylene TCE was commonly used as a solvent by the Department of Defense DoD, as well at private sector facilities. Releases to the environment from its past use make TCE one of the most common contaminants encountered at hazardous waste sites. The Air Force Research Laboratory previously worked with the U.S. Environmental Protection Agency EPA to develop a harmonized physiologically-based pharmacokinetic PBPK model for TCE the model was updated by EPA for their use in their toxicological review. An evaluation of the updated PBPK model will provide insight into the uncertainty associated with its use by EPA.
APPROVED FOR PUBLIC RELEASE