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Effect of a New Local Anesthetic Buffering Device on Pain Reduction During Nerve Block lnjections
Uniformed Services University of the Health Sciences Bethesda United States
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The purpose of this double-blind, split-mouth, randomized human clinical study was to evaluate the effectiveness of a new sodium bicarbonate local anesthetic buffering device Onset, Onpharma in reducing pain associated with dental injections. Twenty patients were given bilateral inferior alveolar IA and long buccal LB nerve block injections and asked to quantify the pain experienced during injection using a visual analog scale VAS. One side of the mouth received standard of care injections using 2 Lidocaine with 1100,000 epinephrine. On the opposite side, injections were administered using 2 Lidocaine with 1100,000 epinephrine buffered 91 with 8.4 sodium bicarbonate using the Onset device to mix the components within the anesthetic carpule. A mean VAS score and standard deviation for the IA injection was 2.7 1.3 for buffered and 2.7 1.9 for unbuffered and for the LB injection was 2.0 1.4 for buffered and 2.7 1.8 for unbuffered. The data were analyzed with a paired t-test alpha0.05. No significant difference was found between groups for the IA p0.94 or the LB injections p0.17.Conclusion Onpharmas Onset local anesthetic buffering technology did not significantly reduce pain from common dental nerve block injections compared to the standard unbuffered injection.
APPROVED FOR PUBLIC RELEASE