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CS Riot Control Agent Exposure in US Army Mask Confidence Training: Association Between Exposure to O-Chlorobenzylidene Malononitrile (CS) and Urinary Metabolite 2-Chlorophippuric Acid

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Technical Report

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Uniformed Services University of the Health Sciences Bethesda United States

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This study was conducted among US Army trainees at Fort Sam Houston, Texas to evaluate the association between exposure to 2-chlorobenzylidene malononitrile CS riot control agent and metabolite 2-chlorohippuric acid CHA measured in urine of test subjects n87 after completion of the Mask Confidence Training chamber exercise. This is the first study to apply personal monitoring and the CDCs CLIA approved CS Metabolites method Code ERB-253 for sensitive analysis of CHA to explore the association between exposure and metabolite in a prospective, observational cohort. Exposure assessment was conducted using OSHA modified P and CAM 304. GCECD was used to quantify CS exposure concentrations. Solid phase extraction and HPLCMS was used to quantify CHA metabolite in urine at pre-exposure, 2, 8, 24, and 30-hour post vii exposure time intervals. Urine samples were creatinine corrected to reduce variation in subject Glomerular filtration rates.

Subject Categories:

  • Chemical, Biological and Radiological Warfare

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