Accession Number:

AD1036327

Title:

The Role of Histone Demethylase Jmjd3 in Immune-Mediated Aplastic Anemia

Descriptive Note:

Technical Report,01 Mar 2016,28 Feb 2017

Corporate Author:

Temple University of the Commonwealth System Philadelphia United States

Personal Author(s):

Report Date:

2017-03-01

Pagination or Media Count:

17.0

Abstract:

Acquired aplastic anemia AA is a condition of bone marrow failure BMF characterized by blood pancytopenia and BM hypoplasia. In most cases, AA is an immune-mediated disorder with destruction of hematopoietic stem and progenitor cells by T cells. There is increasing evidence that CD4 T effector cells that produce high levels of IFN- are associated with AA in patients and experimental AA mice. IFN- displays potent effects on suppressing hematopoiesis. Immunosuppressive therapy with antithymocyte globulin in combination with cyclosporin A CsA can induce a hematologic response in about two-thirds of AA patients. However, relapse occurs in up to 35 of AA patients when CsA is withdrawn at 6 months. Allogeneic BM transplantation BMT has significantly improved the survival of AA. However, graft-versus-host disease GVHD remains a major barrier to the success of the procedure. Novel approaches are needed to improve the outcomes of AA treatment.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE