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Pathomechanics of Post-Traumatic OA Development in the Military Following Articular Fracture
Technical Report,30 Sep 2015,29 Sep 2016
University of Iowa Iowa City United States
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The objective of the proposed research is to develop new models for predicting the risk of post-traumatic osteoarthritis PTOA following intra-articular fracture IAF. Aim 1, pursued this year, involves evaluating pre- and post-treatment CT data from patients with combat-related IAFs to measure fracture severity and post-reduction contact stress exposure. We first established a CRADA between the University of Iowa and the U.S. Army Institute of Surgical Research USAISR. Then IRB approval for access to the patient data from the military medical record was obtained. Our partner at USAISR is screening the DoDTR to identify and enroll subjects. The imaging data for 42 subjects were forwarded to Iowa for analysis, with another 16 subjects identified and their imaging studies requested. As part of an unrelated grant from the NIH, civilian patient data were equivalently analyzed this year, which required refining existing methodologies. Analysis was completed for 31 tibial plafond, 61 tibial plateau, and 17 intra-articular calcaneal fracture cases. We published two papers based on results from those civilian data. Success in analyzing these cases supports our belief that we will be successful in analyzing military CT scan data as they become available.
APPROVED FOR PUBLIC RELEASE