Accession Number:

AD1036302

Title:

Development of a Lubricant Therapy to Prevent Development of Osteoarthritis after Acute Injury of Synovial Joints

Descriptive Note:

Technical Report,30 Sep 2015,29 Sep 2016

Corporate Author:

University of California, San Diego La Jolla United States

Personal Author(s):

• Sah,Robert L.

Report Date:

2016-10-01

Pagination or Media Count:

12.0

Abstract:

Purpose. The prevention of early-onset osteoarthritis after traumatic joint injury remains a clinical challenge and may be associated with the poor lubricant quality of the synovial fluid in the injured joint. Scope. The aims of the studies here were to test whether the pathological accumulation of a specific substance found in joint fluid following an injury mediated altered synovial fluid lubrication of articular cartilage and whether modulation of lubricating molecules could restore lubrication function and prevent cartilage wear. Major Findings. Through studies in year 2, we have delineated the time-dependent changes in lubricant molecule gene expression and biochemical content of joint fluid post-injury in a rabbit model. Progress and Significance. Collection and analysis of human synovial fluid is ongoing Aim 1a, and we have completed most of the analysis of rabbit synovial fluid Aim 1b. From this data, the time-dependent relationship between joint fluid molecules both secretion and gene expression and function could be determined.

Descriptors:

• cartilage
• lubrication
• WEAR
• arthritis
• Friction
• wounds and injuries
• Blood
• joints (anatomy)
• lubricants
• molecules
• gene expression

Subject Categories:

• Anatomy and Physiology
• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE