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Stem Cell Therapy to Improve Burn Wound Healing
Technical Report,15 Feb 2016,14 Feb 2017
University of Miami Coral Gables United States
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Thermal injuries are a significant source of morbidity in times of war, constituting 5 to 20 of all injuries and 4 of all deaths. Although these are usually not life threatening, they cause significant morbidity to the patient and disruption of a deployed military unit. Hypertrophic scaring occurs frequently in operative grafted and non-operative burn wounds and can lead to the formation of scar contractures. Contractures represent a great source of morbidity to burn patients. Scar contracture rates have not evolved with improvements of burn care despite the use of treatments designed to mitigate the effects of hypertrophic scarring including scar massage, topical treatments, steroid injections, and compression garments. Mesenchymal stem cells MSCs have been used in a variety of clinical applications to repair and regenerate damaged tissue. Previous work by our group has demonstrated the safety and efficacy of delivering bone marrow cells including MSCs to chronic wounds with significant improvement in healing and scarring. Application of mesenchymal stem cell MSC therapy to severe burn wounds represents the opportunity for improved outcomes where alternate therapies are limited and often ineffective.
APPROVED FOR PUBLIC RELEASE