GCMS/MS Analyses of Biological Samples in Support of Evaluation of Toxicity Associated with Intravenous Exposure to VX Stereoisomers in Guinea Pigs
Technical Report,01 Jan 2016,31 Aug 2016
Edgewood Chemical Biological Center Aberdeen Proving Ground United States
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This report documents the results of the gas chromatography tandem mass spectrometry analyses of blood, tissues, and organs heart, lung, liver, kidney, and brain that were obtained from guinea pigs intravenously exposed to various concentrations of O-ethyl S-2-diisopropylaminoethyl methylphosphonothioate VX stereoisomers. The amount of O-ethyl methylphosphonofluoridate VX-G present in these biological samples was quantified using chemical ionization mass spectrometry with isotope dilution.
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