PAH Interactions with Soil and Effects on Bioaccessibility and Bioavailability to Humans
Technical Report,01 Jan 2010,01 Jan 2017
Exponent INC Boulder United States
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This work was conducted in response to SERDPs 2010 Statement of Need 10-04 Mechanisms of Contaminant Interaction with Soil Components and its Impact on the Bioavailability of Contaminants. The project evaluated the interactions between polycyclic aromatic hydrocarbons and soils, and how these interactions control the oral and dermal bioavailability of PAHs in soil to humans. The study provides results that can inform assessments and risk management considerations for DoD sites at which PAH-contaminated soils are driving clean-up decisions. The objectives included Task 1 Identify which PAH sources, exposure pathways, and individual PAHs are driving risk assessments and remedial decisions to focus research where it can be most effective Task 2 Develop an understanding of the mechanisms by which PAHs are sequestered in soil, so the magnitude of bioavailability adjustments can be predicted, and to elucidate factors that control the dissolution of PAHs from soil Task 3 Develop an animal model that provides quantitative measures of the relative oral bioavailability of PAHs in soil, and generate a database from this animal model to understand bioavailability across a diversity of soil types and contaminant sources Task 4 Evaluate use of simple in vitro extraction tests to predict in vivo measures of relative bioavailability and, Task 5 Assess the effect of soil-chemical interactions on the dermal absorption of PAHs.
- Organic Chemistry