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HLA-B Sequencing in Patients with Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
59th Medical Wing San Antonio United States
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Stevens-Johnson syndrome SJS and toxic epidermalnecrolysis TEN are severe cutaneous adverse drug reactions ADRs associated with significant morbidity and mortality Figures1-4. Though the exact pathogenesis remains unclear, targeted genomic analysis has identified relationships with certain Immunologic markers and enzymes associated with drug metabolism. HLAB types in particular have been associated withADRs however to date these associations exist for only a few specific drugs and patient populations. Given the unique presentation and ability to obtain target tissue for analysis, severe cutaneous ADRs provide an Ideal target for research using precision medicine techniques. We initially sought to examine whether certain HLAB alleles were present at an increased frequency in patients with SJSTEN. Now through whole genome sequencing and epigenetic analysis, we aim to identify novel biomarkers for cutaneous adverse drug reactions.
APPROVED FOR PUBLIC RELEASE