BACTERICIDAL COATINGS ON TEXTILES FOR REMEDIATION OF INTERMICROBE ACTIVITY (BaCTeRIA) SUMMARY REPORT
Technical Report,01 Oct 2011,30 Sep 2015
ARMY NATICK SOLDIER RESEARCH DEVELOPMENT AND ENGINEERING CENTER MA NATICK United States
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Development of antimicrobials that demonstrate targeted, specific activity against pathogenic strains of interest to the Army provides a promising strategy to protect the Warfighter from pathogenic threats where broad-spectrum antimicrobials may not be applicable. This technical report describes the culmination of work dedicated to the discovery, characterization, analysis and development of a narrow-spectrum antimicrobial that exhibits targeted activity against the surrogate strain of Bacillus anthracis, the microbial agent of anthrax. The antimicrobial agent investigated in this effort was a bacteriocin, a member of a class of antimicrobial peptides secreted by microorganisms to protect against competing microbes in the environment and was discovered from a screen of environmental isolates from Fort Devens. A cost-effective purification protocol was developed to yield sufficient qualities and purities of the bacteriocin to enable its future development. Preliminary investigations were conducted to evaluate the feasibility of synthesizing a multifunctional material with the antimicrobial peptide. Additionally, the production conditions of the bacteriocin from its producer organism was investigated to generate the optimal growth media for high quantities of bacteriocin production. The work cited in this report provides the foundation for future studies to further characterize and develop a novel application employing the bacteriocin in a construct that facilitates antimicrobial protection for the Warfighter.
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