Gene Expression Profile of Human Cytokines in Response to B.pseudomallei Infection
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USAMRIID Ft Detrick United States
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Melioidosis, is an under-reported infectious disease, caused by the gram-negative bacterium Burkholderia pseudomallei. Understanding disease pathogenesis and susceptibility is crucial for developing newer diagnostic and therapeutic strategies for this life threatening infection. In this study, we aimed to analyze the gene expression levels of important cytokines in melioidosis patients and establish useful correlates with disease biomarkers compared to cases of sepsis infection caused by other pathogens and healthy individuals. A Qiagen common human cytokines array, profiling the gene expression of 84 important cytokines by real time quantitative polymerase chain reaction RT qPCR was used.
- Medicine and Medical Research