Targeting Transcription Elongation Machinery for Breast Cancer Therapy
Technical Report,15 Apr 2016,14 Apr 2017
University of California, Berkeley Berkeley United States
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This project focuses on the important but under-studied role of the P-TEFb-dependent transcription elongation machinery in human breast cancer progression. It aims to test the hypothesis that transcription elongation is a key regulatory step in breast cancer development, and that targeting P-TEFb can be an effective strategy to block breast cancer progression. During the current reporting period, we have made significant progress toward the identification of the ELL2-containing SEC as the form of active P-TEFb that plays a key role in promoting breast cancer cell EMT.
- Medicine and Medical Research