Accession Number:

AD1035753

Title:

Targeting Transcription Elongation Machinery for Breast Cancer Therapy

Descriptive Note:

Technical Report,15 Apr 2016,14 Apr 2017

Corporate Author:

University of California, Berkeley Berkeley United States

Personal Author(s):

Report Date:

2017-05-01

Pagination or Media Count:

16.0

Abstract:

This project focuses on the important but under-studied role of the P-TEFb-dependent transcription elongation machinery in human breast cancer progression. It aims to test the hypothesis that transcription elongation is a key regulatory step in breast cancer development, and that targeting P-TEFb can be an effective strategy to block breast cancer progression. During the current reporting period, we have made significant progress toward the identification of the ELL2-containing SEC as the form of active P-TEFb that plays a key role in promoting breast cancer cell EMT.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE