Accession Number:
AD1035753
Title:
Targeting Transcription Elongation Machinery for Breast Cancer Therapy
Descriptive Note:
Technical Report,15 Apr 2016,14 Apr 2017
Corporate Author:
University of California, Berkeley Berkeley United States
Personal Author(s):
Report Date:
2017-05-01
Pagination or Media Count:
16.0
Abstract:
This project focuses on the important but under-studied role of the P-TEFb-dependent transcription elongation machinery in human breast cancer progression. It aims to test the hypothesis that transcription elongation is a key regulatory step in breast cancer development, and that targeting P-TEFb can be an effective strategy to block breast cancer progression. During the current reporting period, we have made significant progress toward the identification of the ELL2-containing SEC as the form of active P-TEFb that plays a key role in promoting breast cancer cell EMT.
Descriptors:
Subject Categories:
- Medicine and Medical Research