Accession Number:

AD1035710

Title:

Cell Penetrating Bispecific Antibodies for Targeting Oncogenic Transcription Factors in Advanced Prostate Cancer

Descriptive Note:

Technical Report,30 Sep 2012,29 Sep 2016

Corporate Author:

Medical University of South Carolina Charleston United States

Personal Author(s):

Report Date:

2016-12-01

Pagination or Media Count:

12.0

Abstract:

The goal of these studies is to develop and validate cell-penetrating bi-specific antibodies as an agent that can selectively inhibit the function of intracellular proteins. We have developed 3E10-AR441 bi-specific antibody to inhibit the function both ligand-dependent and independent forms of the androgen receptor AR, key drivers of prostate carcinogenesis.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE