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Brain Consequences of Spinal Cord Injury with and without Neuropathic Pain: Translating Animal Models of Neuroinflammation onto Human Neural Networks and Back

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Technical Report,15 Sep 2015,14 Sep 2016

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Children's Hospital Corporation Boston United States

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This project aims to investigate the consequence of spinal cord injury with regards to alterations in brain network function and expression of activated microglia, both human patients and in an animal model. During year one, we have Obtained IRB and HRPO approval for the human studies, obtained IACUC and ACURO approval for the animal studies, refined the human study protocol and collected PET-MR data on healthy individuals and spinal cord injured subjects, developed the rodent imaging procedures including awake rat fMRI, collected pilot PET and MRI rat data, refined the spinal cord injury model. Human imaging data is of consistently high quality and is reliably collected, albeit with some concerns regarding patient recruitment being slower than anticipated. Animal imaging data is of sufficient quality, and efforts are underway to improve animal data collection. The animal spinal cord injury model has been refined. Data collection has been delayed due to regulatory procedures with regards to IACUC approvals, personnel training and personnel turnover.

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  • Medicine and Medical Research

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