Understanding the Connection Between Traumatic Brain Injury and Alzheimer's Disease: A Population Based Medical Record Review Analysis
Technical Report,15 Sep 2015,14 Sep 2018
Mayo Clinic Rochester United States
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Purpose The most accurate and reliable study design to determine whether the occurrence of TBI increases risk for the development of Alzheimers disease and related disorders ADRD is to identify incident TBI events by medical record review within a defined population and classify each by injury severity, identify matched referents within that same population, and follow both cohorts over time to observe incidence rates of ADRD. Scope Compared to other study designs, our approach significantly reduces the methodological problems of referral and recall bias, and selective survival, which have limited the scientific communitys ability to determine whether TBI is indeed associated with an increased risk of ADRD. There are no published reports of a population-based analysis matching TBI cases, identified by medical record review and classified by injury severity into 3 strata, to population-based referents with non-head trauma. This is particularly important as non-head trauma may also increase the risk of ADRD. Major Findings 6,939 individuals with 9,665 code dates for index injuries that occurred at or after the age of 40 years have been identified within the study period. 5,430 records of individuals 78 of total that include 7,565 code dates have been reviewed, yielding 1,142 confirmed cases yield rate of 21.
- Medicine and Medical Research
- Anatomy and Physiology