The Impact of PERK on Posttraumatic Tauopathy in Alzheimer's Disease
Technical Report,15 Sep 2015,14 Sep 2016
University of Kentucky Lexington United States
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Risk for AD is one of the most imminent threats to military personnel sustaining TBI. A major challenge in the field of TBIAD research is elucidation of the molecular mechanisms linking TBI with tau pathogenesis that is associated with AD. This critical and urgently needed information will identify novel therapeutic targets that will benefit both military personnel and civilian population. Our recent data indicate that TBI induces sustained and dramatic endoplasmic reticulum stress, and that there is a pathological relationship between AD tau species and the ER stress sensor PERK. For the first time, we directly address the role PERK activity as a molecular mediator of TBI induced tau pathology and provide unique understanding of the association between TBI and AD. Therapies aiming to interrupt the molecular events identified by this work will be monitored using our imaging technology known as MEMRI. Finally, our work will test the therapeutic value of inhibiting the PERK, which is involved inseveral neurodegenerative disorders.
- Medicine and Medical Research