Localizing and Assessing Amputee Pain with Intense Focused Ultrasound
Technical Report,15 Sep 2015,14 Sep 2016
University of Washington, Dept. of Neurological Surgery Seattle United States
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Here we propose exploratory studies to stimulate subcutaneous pain generators in patients within residual limbs using research image-guided intense focused ultrasound ig-iFU system. Out targets for iFU stimulation include neuromas, intact nerves, TMR targeted muscle reinnervation sites, and patient-identified sensitive areas. Successful application of iFU to deep, potentially painful tissue should allow us to locate that tissue and compare their relative sensitivity to external stimulation. This would be consistent with our preliminary human data. Also, our rat studies suggest it plausible that painful tissue in humans would require less ultrasound to generate a sensation than surrounding tissue. We specifically anticipate that we will show that TMR sites are less sensitive than neuromas. This and our questionnaire studies will support the view that TMR surgery may reduce amputee pain relative to standard amputation surgery.
- Medicine and Medical Research
- Anatomy and Physiology