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Accession Number:
AD1034081
Title:
Local Tacrolimus (FK506) Delivery for Prevention of Acute Rejection in the Nonhuman Primate Delayed Mixed Chimerism Vascularized Composite Allograft Tolerance Induction Protocol
Descriptive Note:
Technical Report,15 Sep 2015,14 Sep 2016
Corporate Author:
Massachusetts General Hospital Boston United States
Report Date:
2016-10-01
Pagination or Media Count:
14.0
Abstract:
The focus for Year 1 was to develop a polymeric local delivery system PLDS for tacrolimus FK506, and characterize in vitro. The work included selecting and characterizing the polymer for the PLDS, optimizing a fabrication method, and developing characterization methods to test the pharmacokinetics after drug loading. To this end, the team synthesized and characterized a batch of the chosen tyrosine-derived polymer formulation, E12181k, and moved forward in finalizing the fabrication method for the PLDS. Method development for in-depth pharmacokinetic studies is currently underway, and preclinical animal studies are currently being planned for testing the PLDS in a small animal model as well as a non-human primate model.
Distribution Statement:
APPROVED FOR PUBLIC RELEASE