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Local Tacrolimus (FK506) Delivery for Prevention of Acute Rejection in the Nonhuman Primate Delayed Mixed Chimerism Vascularized Composite Allograft Tolerance Induction Protocol
Technical Report,15 Sep 2015,14 Sep 2016
Massachusetts General Hospital Boston United States
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The focus for Year 1 was to develop a polymeric local delivery system PLDS for tacrolimus FK506, and characterize in vitro. The work included selecting and characterizing the polymer for the PLDS, optimizing a fabrication method, and developing characterization methods to test the pharmacokinetics after drug loading. To this end, the team synthesized and characterized a batch of the chosen tyrosine-derived polymer formulation, E12181k, and moved forward in finalizing the fabrication method for the PLDS. Method development for in-depth pharmacokinetic studies is currently underway, and preclinical animal studies are currently being planned for testing the PLDS in a small animal model as well as a non-human primate model.
APPROVED FOR PUBLIC RELEASE