Accession Number:

AD1034081

Title:

Local Tacrolimus (FK506) Delivery for Prevention of Acute Rejection in the Nonhuman Primate Delayed Mixed Chimerism Vascularized Composite Allograft Tolerance Induction Protocol

Descriptive Note:

Technical Report,15 Sep 2015,14 Sep 2016

Corporate Author:

Massachusetts General Hospital Boston United States

Personal Author(s):

• Cetrulo,Curtis L.

Report Date:

2016-10-01

Pagination or Media Count:

14.0

Abstract:

The focus for Year 1 was to develop a polymeric local delivery system PLDS for tacrolimus FK506, and characterize in vitro. The work included selecting and characterizing the polymer for the PLDS, optimizing a fabrication method, and developing characterization methods to test the pharmacokinetics after drug loading. To this end, the team synthesized and characterized a batch of the chosen tyrosine-derived polymer formulation, E12181k, and moved forward in finalizing the fabrication method for the PLDS. Method development for in-depth pharmacokinetic studies is currently underway, and preclinical animal studies are currently being planned for testing the PLDS in a small animal model as well as a non-human primate model.

Descriptors:

• immunosuppression
• transplants
• models
• POLYMERS
• fabrication
• pharmacokinetics
• TYROSINE
• safety
• MELTING POINT
• Glass transition temperature

Subject Categories:

• Medicine and Medical Research
• Pharmacology
• Polymer Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE