Prevention and Treatment of Breast Cancer
Technical Report,15 Jul 2015,14 Jul 2016
Albany Medical College Albany United States
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The purpose of this project is to test the hypothesis that AFPep is safe and effective for prevention and treatment of breast cancer. Aim 1 is to document the preventive efficacy and safety of AFPep. The data reported herein allow us to conclude that AFPep prevents estrogen-induced breast cancer in ACI rats just as it prevented carcinogen-induced breast cancer in Sprague Dawley rats. From the ACI rat model, together with data in primates primate work not supported by CDMRP and data from dogs, we conclude that AFPep is extraordinarily safe. Aim 2 is to measure and maintain blood levels of AFPep at effective doses in mice, dogs, and non-human primates. Assessing pharmacokinetic data in mice and primates, we conclude that an efficacious blood level of AFPep is approximately 1 gmL, and this blood level can easily be achieved in higher mammals with no evidence of toxicity. Although there is important work to be done in Years 2 and 3 of this grant, we conclude from the data of Year 1 that AFPep is safe and effective for the prevention and treatment of breast cancer, and should proceed to clinical trials for the prevention of breast cancer as soon as possible.
- Medicine and Medical Research