Protective Role of Angiogenin Against Hematopoietic Syndrome of the Acute Radiation Syndrome
Technical Report,05 Aug 2015,04 Aug 2016
Tufts Medical Center Boston United States
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We have examined the function of angiogenin ANG in radiation-induced cell damage by examining the differential effect of -radiation toward WT and Ang-- mice. We have found that ANG deficiency reduced survival, accompanied by reduced HSPC and LymPro number and more active cycling, but reduced MyePro number with restricted proliferation irradiation. We have also assessed the therapeutic activity of recombinant ANG protein and found that treatment with ANG protein, either prior to or post -irradiation, significantly extended mice survival, accompanied by recovery of BM cellularity, leukocyte counts, cell numbers of HSPC, LymPro and MyePro. Significantly, cell cycle status of HSPC and LymPro decreased whereas that of MyePro increased upon ANG treatment in irradiated mice. Together, we have demonstrated the protective and mitigative functions of ANG against radiation-induced BM damage, likely through induction of HSPC quiescence and promotion of MyePro proliferation.
- Medicine and Medical Research