Accession Number:

AD1033982

Title:

Ex Vivo Machine Perfusion in VCA with a Novel Oxygen Carrier System to Enhance Graft Preservation and Immunologic Outcomes

Descriptive Note:

Technical Report,15 Sep 2013,14 Sep 2016

Corporate Author:

University of Pittsburgh Pittsburgh United States

Personal Author(s):

Report Date:

2016-12-01

Pagination or Media Count:

62.0

Abstract:

The objective of this proposal is to establish the graft preservation and immunomodulatory effects of our MP-BMPSHBOC system in a pre-clinical large animal CTA model. We will specifically address the following specific aims in a porcine vascularized musculo-adipo-cutaneous flap model Aim 1 Does MP-BMPSHBOC allow prolongation of CIT without significant cellular damage to the allograft Aim 2 Does the MP-BMPSHBOC minimize the effects and incidence of ischemia-reperfusion injury at revascularization Aim 3 What is the effect of MP-BMPSHBOC on the immune profile of various flap tissues after transplantation

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE