Enhancing Immune Checkpoint Inhibitor Therapy In Kidney Cancer
Technical Report,30 Sep 2015,29 Sep 2016
JOHNS HOPKINS UNIV BALTIMORE MD BALTIMORE United States
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The purpose of this research is to test therapeutic strategies to make immune checkpoint inhibition more effective in an animal model of kidney cancer. Our plan is to combine focally ablative techniques such as radiation or cry therapy with PD1 immune checkpoint inhibition and assess the abscopal effect, i.e. the growth of tumors at a distant, untreated site. Additionally, we will test the effect of TLR agonist administration in this model and look at combination with focally ablative techniques.