Combating Posttraumatic Osteoarthritis via Enhanced Intra-Articular Recruitment of Stem Cells and Targeting Delivery of a Chondrogenic Agent
Technical Report,01 Jul 2015,31 Jul 2016
William Beaumont Hospital Research Institute Royal Oak United States
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The focus of this project is to utilize an in situ regenerative medicine-based approach to mitigate the onset and progression of post-traumatic osteoarthritis PTOA following rupture of the anterior cruciate ligament ACL. Though a preliminary finding, our group has validated that rupture of the anterior cruciate ligament ACL in the knee results in a significant increase in the number of marrow-derived mesenchymal stem cell circulating in peripheral blood. We have also determined that these cells in circulation migrate preferentially to the injured knee and engraft within the synovium. This potentially validates our hypothesis that additional molecular signals chemokines are needed to increase the recruitment of stem cells inside the injured joint to mitigate the onset and progression of post-traumatic osteoarthritis. Work is no underway using chimeric animals with marrow cells that express green fluorescent protein.
- Medicine and Medical Research