New Strategies in Targeted Interventions for Posttraumatic Osteoarthritis (PT-OA)
Technical Report,01 Jul 2015,30 Jun 2016
CONNECTICUT UNIV HEALTH CENTER FARMINGTON FARMINGTON United States
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The subject of this project is Post-Traumatic Osteoarthritis PT-OA, which is a form of Osteoarthritis OA with particularly rapid onset that leads to painful and disabling disease in otherwise healthy and relatively young adults,including military service members who have sustained traumatic joint injuries. This project will provide mechanistic proof-of-concept for our hypothesis that stimulating anabolic cartilage responses, and inhibiting catabolic ones, will slow the onset or progression of PT-OA following traumatic joint injury. The project will investigate the mechanistic involvement of EGFR growth factor signaling in mediating anabolic and catabolic responses in articular cartilage, and will develop strategies for modulating EGFR signaling in the joint as a means to control EGFR-mediated anabolic and catabolic responses. The impact of the project is to provide proof-of-concept support for a new mechanistically-based therapeutic intervention for PT-OA.
- Medicine and Medical Research
- Anatomy and Physiology