Accession Number:

AD1033797

Title:

Dietary Approaches to Protect Against Eye Blast Induced Oxidative Stress and Vision Loss

Descriptive Note:

Technical Report,30 Sep 2015,29 Sep 2016

Corporate Author:

Vanderbilt University Nashville United States

Personal Author(s):

Report Date:

2016-11-01

Pagination or Media Count:

9.0

Abstract:

The premise of this study was that oxidative stress contributes significantly to the progressive cell death and neuronal degeneration that we detect after ocular trauma and, thus, treating with Vitamins C and E or a ketogenic diet would be protective. We have completed at least one cohort for each experimental condition and plan to repeat the studies to confirm our findings. We expect the project to be complete in another year, if we continue it. Preliminarily our results suggest that removal of Vit.C is detrimental to outcomes after blast exposure, however, additional Vit.C and Vit.E in animals that already produce sufficient levels, has no protective effect. The ketogenic diet also did not elicit a protective effect after blast. Rather, we detected an increase in the inflammatory cytokine, IL-1 and a decrease in the oscillatory potential of the electroretinogram independent of trauma. In summary, neither diet appears to be protective, however, we may have identified IL-1 as an important mediator of vision loss after ocular trauma.

Subject Categories:

  • Food, Food Service and Nutrition
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE