Harnessing Neuroplasticity to Promote Rehabilitation: CI Therapy for TBI
Technical Report,30 Sep 2015,29 Sep 2016
University of Alabama at Birmingham Birmingham United States
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This study will evaluate Constraint-Induced Movement CI therapy for promoting motor recovery in veterans and civilians with traumatic brain injury TBI. This form of physical rehabilitation has been shown to substantially improve motor function after brain injury not due to trauma and to provoke a widespread neuroplastic response in the brain. This study N 80 is a single blind, randomized controlled trial that compares CI therapy for improving use of the more-affected arm in adults with TBI to a holistic fitness program named Lakeshore Enriched Fitness Training LEFT. In addition to assessing changes from pre-treatment in more-affected arm motor function at post-treatment and 1-year afterwards, changes will be examined in white matter, grey matter, and functional brain activity. Products at the end of the first year of this blinded study are a manual of procedures and a method for generating synthetic neuroimaging data for the purpose of evaluating the sensitivity of the techniques proposed for quantifying changes in grey matter.
- Medicine and Medical Research