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Development of a Personalized Model for Pressure Ulcer Prevention Acutely Following Spinal Cord Injury: Biomarkers of Muscle Composition and Resilience

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Technical Report,30 Sep 2015,29 Sep 2016

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Cleveland VA Medical Research and Education Foundation Cleveland United States

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Development of a pressure ulcer acutely following spinal cord injury SCI has a devastating impact on the progress of initial rehabilitation for too many active duty military and veterans. All persons with SCI are at increased risk of pressure ulcer development which remains one of the most significant secondary complications for these individuals. Susceptibility appears to be unique for each individual. Changes in soft tissue composition and function following SCI may provide the key to personalized risk status which the clinician can employ to determine each individuals optimal pressure ulcer prevention regime. Good risk assessment tools are currently not available to reliably identify the individual with acute SCI at risk of pressure ulcers. This project is investigating potential linkages between skeletal muscle tissue biomarkers and tissue resilience under applied loads in individuals with acute SCI at risk for pressure ulcer development. In the first six months of this observational study we have developed a framework for an objective pressure ulcer risk assessment tool to reliably identify more susceptible individuals within this high-risk population and provide the basis for personalized clinical management of tissue health. Recruitment and data collection are ongoing to collate patient data on tissue health and muscle composition.

Subject Categories:

  • Medicine and Medical Research
  • Anatomy and Physiology

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