Accession Number:

AD1033527

Title:

Towards a Molecular Understanding of Noise-Induced Hearing Loss

Descriptive Note:

Technical Report,30 Sep 2015,29 Sep 2016

Corporate Author:

University of Maryland School of Medicine Baltimore United States

Personal Author(s):

Report Date:

2016-10-01

Pagination or Media Count:

21.0

Abstract:

The purpose of this project is to generate the cell type-specific molecular blueprint of changes in gene expression following different types of noise exposure and their treatments, in the inner ear. To this end, we have a Established the hair cell and supporting cell-specific translatome of adult mouse inner ears b Established the molecular changes induced by PTS-resulting noise exposure in hair cells, support cells and whole inner ears, 6 and 24 hours after noise exposure c Collected and processed most of the tissue for TTS-resulting noise exposure. In addition, we have two manuscripts in preparation describing findings that arose as sub-projects of the main proposal.

Subject Categories:

  • Medicine and Medical Research
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE