Towards a Molecular Understanding of Noise-Induced Hearing Loss
Technical Report,30 Sep 2015,29 Sep 2016
University of Maryland School of Medicine Baltimore United States
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The purpose of this project is to generate the cell type-specific molecular blueprint of changes in gene expression following different types of noise exposure and their treatments, in the inner ear. To this end, we have a Established the hair cell and supporting cell-specific translatome of adult mouse inner ears b Established the molecular changes induced by PTS-resulting noise exposure in hair cells, support cells and whole inner ears, 6 and 24 hours after noise exposure c Collected and processed most of the tissue for TTS-resulting noise exposure. In addition, we have two manuscripts in preparation describing findings that arose as sub-projects of the main proposal.
- Medicine and Medical Research
- Anatomy and Physiology