Accession Number:

AD1033525

Title:

Inflammation Modulatory Protein TSG-6 for Chemical Injuries to the Cornea

Descriptive Note:

Technical Report,30 Sep 2015,29 Sep 2016

Corporate Author:

TEMPVA Research Group Temple United States

Personal Author(s):

Report Date:

2016-10-01

Pagination or Media Count:

27.0

Abstract:

During this study period we initiated testing to evaluate the effectiveness TSG-6 applied intravenously IV after corneal alkali burn in the rat model, and completed the setup of equipment and facilities for TSG-6 production for intravenous studies at the Central Texas Veterans Health Care System Research building, after the migration of the Texas A and M Institute of Regenerative Medicine from Temple, Texas to College Station, Texas. We found that lower dose IV TSG-6 applied singly immediately after injury did not provide a statistically significant benefit to the cornea after alkali injury as evaluated by corneal clarity and by biochemical markers of inflammation. Experiments to test the effectiveness of higher dose IV TSG-6, with and without topical TSG-6, are underway.

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE