Variable Saline Concentrations for Initial Resuscitation Following Polytrauma
Technical Report,01 Aug 2014,01 Oct 2016
USAFSAM/FHE Wright-Patterson AFB United States
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Optimal resuscitation fluid of the injured patient has yet to be established. We investigated the utility of standard variable saline concentrations 0.9 , 3 , 23.4 in a murine polytrauma model of traumatic brain injury and hemorrhagic shock. Animals were evaluated for survival, hemodynamics, physiologic, and inflammatory response following injury and resuscitation. Our results demonstrated that high-concentration, low-volume saline resuscitation leads to increased mortality despite decreased posttraumatic cerebral edema. In addition, 3 saline may be the optimal crystalloid fluid to resuscitate in the setting of hypotension after head injury, as it limits ongoing inflammation, cerebral edema, and neurologic injury while preserving blood pressure and survival.