Dissecting Neuronal Participation to Focal Epileptic Events in Vivo
Technical Report,30 Sep 2015,29 Sep 2016
Baylor College of Medicine Houston United States
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Epilepsy is prevalent among Veterans conferring significant morbidity. Despite decades of study, its circuit mechanisms remain poorly understood. To develop rational approaches to therapy we need to understand the role that individual neurons of different types play in epileptic events. The two-photon, optical micro-encephalogram is a powerful tool for dissecting circuit mechanisms of epilepsy, by allowing us to follow the activity of individual units chronically in vivo. We use this method and patch-clamp to study the well-validated Tetanus Toxin model of focal epilepsy. Our goal is to map how different types of cortical neurons get recruited to seizures and epileptiform EEG events over time as focal epilepsy sets in, while identifying the role that different cell types play in its manifestations. In this 1st report, from 10115 to 612016, we met our SOW goals to hiretrain a dedicated postdoc, develop the experimental paradigm, and begin studying the role of pyramidal neurons. We request the transfer of the award to Boston JP VA, where the PI relocated, without additional cost. Aims and key personnel will remain identical.
- Medicine and Medical Research
- Anatomy and Physiology