Accession Number:

AD1033283

Title:

microRNA in Cerebral Spinal Fluid as Biomarkers of Alzheimer's Disease Risk After Brain Injury

Descriptive Note:

Technical Report,01 Aug 2015,31 Jul 2016

Corporate Author:

Oregon Health and Science University Portland United States

Personal Author(s):

Report Date:

2016-08-01

Pagination or Media Count:

8.0

Abstract:

A history of TBI increases the odds of developing AD by 2.5 times in the general population, and 4-6 times for military veterans. Although significant associations between mTBI and risk of AD have been observed, the precise mechanism by which TBI might lead to AD andor AD-related symptoms are not yet understood. Histologically, AD is characterized by amyloid- and neurofibrillary protein aggregates, suggesting a loss of protein processing is a key feature of AD. MiRNAs are small non-coding RNA that regulate mRNA transcription, and may be a significant cause of protein dysregulation.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE