microRNA in Cerebral Spinal Fluid as Biomarkers of Alzheimer's Disease Risk After Brain Injury
Technical Report,01 Aug 2015,31 Jul 2016
Oregon Health and Science University Portland United States
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A history of TBI increases the odds of developing AD by 2.5 times in the general population, and 4-6 times for military veterans. Although significant associations between mTBI and risk of AD have been observed, the precise mechanism by which TBI might lead to AD andor AD-related symptoms are not yet understood. Histologically, AD is characterized by amyloid- and neurofibrillary protein aggregates, suggesting a loss of protein processing is a key feature of AD. MiRNAs are small non-coding RNA that regulate mRNA transcription, and may be a significant cause of protein dysregulation.