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Primary Blast Injury Criteria for Animal/Human TBI Models using Field Validated Shock Tubes

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Technical Report,15 Aug 2015,14 Aug 2016

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New Jersey Institute of Technology Newark United States

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Injury severity in blast induced Traumatic Brain Injury bTBI increases with blast overpressure BOP and impulse in dose-dependent manner. Pure primary blast waves were simulated in compressed gas shock-tubes in discrete increments. We evaluated 24 hour survival of rats in 0-450 kPa 0-800 Pas impulse range at 10 discrete levels 60, 100, 130, 160, 190, 230, 250, 290, 350 and 420 kPa and determined the mortality rate as a non-linear function of BOP. Using logistic regression model, predicted mortality rate PMR function was calculated, and used to establish TBI severities. We determined a BOP of 145 kPa as upper mild TBI threshold 5 PMR. Also we determined 146-220 kPa and 221-290 kPa levels as moderate and severe TBI based on 35, and 70 PMR, respectively, while BOP above 290 kPa is lethal.

Subject Categories:

  • Medicine and Medical Research
  • Anatomy and Physiology
  • Test Facilities, Equipment and Methods

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