Alterations in Gut Microbiota and Post-Traumatic Osteoarthritis
Technical Report,24 Aug 2015,23 Aug 2016
Cornell Univ Ithaca United States
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The purpose of this project is to understand how metabolic factors regulate the development of post-traumatic osteoarthritis. Specifically, the goals of this project are to test the idea that alterations in systemic inflammation caused by changes in the gut microbiota promote the occurrence of post-traumatic osteoarthritis. The project examines the development of osteoarthritis following a single overload to the knee joint under conditions of altered gut microbiota caused by genetic background or chronic antibiotic treatment. In the first year of this project we have made considerable progress, receiving approval from institutional animal care and use ethical reviews, performing animal breeding and mechanical stimulations known to cause the development of osteoarthritis in control groups. At this time we have completed all live animal experimentation in the project and have started data analysis. Early results from the project suggest that alterations in the gut microbiota are causing changes in bone tissue mechanical properties that may mediate the effects of mechanical overloads on subsequent cartilage degeneration.
- Medicine and Medical Research
- Anatomy and Physiology