Accession Number:

AD1033257

Title:

Alterations in Gut Microbiota and Post-Traumatic Osteoarthritis

Descriptive Note:

Technical Report,24 Aug 2015,23 Aug 2016

Corporate Author:

Cornell Univ Ithaca United States

Personal Author(s):

Report Date:

2016-09-01

Pagination or Media Count:

19.0

Abstract:

The purpose of this project is to understand how metabolic factors regulate the development of post-traumatic osteoarthritis. Specifically, the goals of this project are to test the idea that alterations in systemic inflammation caused by changes in the gut microbiota promote the occurrence of post-traumatic osteoarthritis. The project examines the development of osteoarthritis following a single overload to the knee joint under conditions of altered gut microbiota caused by genetic background or chronic antibiotic treatment. In the first year of this project we have made considerable progress, receiving approval from institutional animal care and use ethical reviews, performing animal breeding and mechanical stimulations known to cause the development of osteoarthritis in control groups. At this time we have completed all live animal experimentation in the project and have started data analysis. Early results from the project suggest that alterations in the gut microbiota are causing changes in bone tissue mechanical properties that may mediate the effects of mechanical overloads on subsequent cartilage degeneration.

Subject Categories:

  • Medicine and Medical Research
  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE