Development of Less Toxic Treatment Strategies for Metastatic and Drug-Resistant Breast Cancer Using Noninvasive Optical Monitoring
Technical Report,01 Sep 2015,31 Aug 2016
Trustees of Boston University Boston United States
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This project involves the development of optically guided multi-agent therapies for metastatic and drug resistant breast cancer. Non-invasive Diffuse Optical Imaging technologies are able to monitor drug response and resistance through quantitative tracking of tumor metabolism and vascular supply, using clinic friendly and portable devices that can monitor deep lesions multiple centimeters below the skin in both breast tissue and at the site of bone metastases. During year 1 of the project we have received institutional IACUC approval as well as ACURO approval. We have successfully set up a new long wavelength intravital multiphoton microscopy system that will be important for future work on the project. We have conducted initial in vivo and ex vivo mouse imaging experiments with the system. We have also fabricated a new long wavelength Spatial Frequency Domain Imaging SFDI small animal imaging system and demonstrated imagining capability up to 1300 nm for the first time, which will allow for deep tissue extractions of hemoglobin, lipid, and collagen concentrations.
- Medicine and Medical Research