Accession Number:

AD1033200

Title:

Vitamin D Supplementation for Prevention of Post-Traumatic Osteoarthritis: Evaluation in Animal and Clinical Models

Descriptive Note:

Technical Report,22 Sep 2015,06 Oct 2016

Corporate Author:

University of Connecticut Farmington United States

Personal Author(s):

Report Date:

2016-10-25

Pagination or Media Count:

42.0

Abstract:

The goals of this translational study are to create an animal model of joint injury and evaluate the impact of Vitamin D in prevention and progression of PTOA. Concurrently, we will evaluate a clinical cohort of USMA cadets treated for ACL tear, with pre- and post-injury serum 25-hydroxy-Vitamin D levels and correlation with joint space narrowing and biomarkers of cartilage injury. If Vitamin D supplementation can prevent the onset of often rapid joint destruction that occurs with PTOA, this simple, safe, and inexpensive intervention could potentially translate to pre-emptive treatment for high-risk military occupations. In addition, Vitamin D could be used at the time of injury to possibly mitigate ongoing articular cartilage damage.

Subject Categories:

  • Biochemistry
  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE