Vitamin D Supplementation for Prevention of Post-Traumatic Osteoarthritis: Evaluation in Animal and Clinical Models
Technical Report,22 Sep 2015,06 Oct 2016
University of Connecticut Farmington United States
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The goals of this translational study are to create an animal model of joint injury and evaluate the impact of Vitamin D in prevention and progression of PTOA. Concurrently, we will evaluate a clinical cohort of USMA cadets treated for ACL tear, with pre- and post-injury serum 25-hydroxy-Vitamin D levels and correlation with joint space narrowing and biomarkers of cartilage injury. If Vitamin D supplementation can prevent the onset of often rapid joint destruction that occurs with PTOA, this simple, safe, and inexpensive intervention could potentially translate to pre-emptive treatment for high-risk military occupations. In addition, Vitamin D could be used at the time of injury to possibly mitigate ongoing articular cartilage damage.
- Anatomy and Physiology
- Medicine and Medical Research