Spinal Cord Swelling and Alterations in Hydrostatic Pressure After Acute Injury
Technical Report,30 Sep 2015,29 Sep 2016
University of British Columbia, ICORD, Blusson Spinal Cord Centre Vancouver Canada
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In Year 2 of this award we examined whether duraplasty after acute thoracic spinal cord injury SCI in a porcine model could improve long-term functional outcome after injury. We finalized the 12-week PTIBS analysis as well as the somatosensory-evoked potential, which was recorded at baseline, 3 hours post injury and at the final week of the study 12 weeks post SCI. Our data suggest that duraplasty surgery might improve functional recovery early after SCI compared to SCI-animals without duraplasty. In Year 2 we also started surgeries as part of Aim 2 to determine if surgically expanding the subarachnoid space with a duraplasty will alter intraparenchymal spinal cord pressure, SCBF, and metabolic responses monitored over a 7-day period. During these surgeries, we inserted a total of six probes into the spinal cord in order to be able to measure the blood flowoxygenation, pressure and microdialysis responses distal proximal 2mm and 22mm to the impact site. The data are too preliminary for one to draw firm conclusions. Additional surgeries will be performed in YEAR 3 of the grant.
- Medicine and Medical Research
- Anatomy and Physiology