Annexin A2 in Proliferative Vitreoretinopathy
Technical Report,30 Sep 2015,29 Sep 2016
Weill Medical College of Cornell University New York United States
Pagination or Media Count:
Proliferative vitreoretinopathy PVR is a potentially blinding disorder that occurs in almost one-half of military personnel who have suffered a penetrating wound to the eye. PVR involves migration of pigmented retinal epithelial RPE cells from theoutermost layer of the retina to the innermost layer at the point of retinal penetration, with subsequent epiretinal membrane orscar formation. We have discovered that when we induce an eye injury in mice that lack a protein called annexin A2 ANXA2,the PVR process is greatly attenuated, and scar formation rarely occurs. In the past year, we have shown that RPE cellslacking ANXA2 fail to migrate in the presence of macrophages in an in vitro system. In addition, analysis of human retinal tissue from subjects undergoing ocular surgery for PVR reveals the presence of A2-immunoreactive cells within the PVR scar.In the third year of this project, we plan to explore the molecular mechanism whereby ANXA2 is required for RPE cell migration induced by macrophages. In addition, we will examine the effects of blockade of ANXA2 activity on macrophage-induced RPEcell migration in vitro, and PVR development in our mouse model. We hope that this work will lead to new approaches to the treatment of PVR in humans.
- Medicine and Medical Research