Accession Number:

AD1033113

Title:

Microenvironments and Signaling Pathways Regulating Early Dissemination, Dormancy, and Metastasis

Descriptive Note:

Technical Report,01 Sep 2015,31 Aug 2016

Corporate Author:

Mount Sinai School of Medicine New York, United States

Personal Author(s):

Report Date:

2016-09-01

Pagination or Media Count:

99.0

Abstract:

We devoted effort to both aims, to optimize methods and publish the first phase of efforts. SA1 is to understand the intrinsic mechanisms of dissemination by early-progressed cancer cells and how the microenvironment in these primary sites named P-TMEM Primary Tumor Microenvironment of Metastases contribute to early dissemination. We now have new data suggesting that a signature of early dissemination markers consisting on HER2HIp-ATF2LOE-cadhLO could identify motile early-progressed tumor cells and predict for dissemination. We further show that mammary tissue macrophages and HER2HIp-ATF2LOE-cadhLO tumor cells cooperate to disseminate early.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE