Microenvironments and Signaling Pathways Regulating Early Dissemination, Dormancy, and Metastasis
Technical Report,01 Sep 2015,31 Aug 2016
Mount Sinai School of Medicine New York, United States
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We devoted effort to both aims, to optimize methods and publish the first phase of efforts. SA1 is to understand the intrinsic mechanisms of dissemination by early-progressed cancer cells and how the microenvironment in these primary sites named P-TMEM Primary Tumor Microenvironment of Metastases contribute to early dissemination. We now have new data suggesting that a signature of early dissemination markers consisting on HER2HIp-ATF2LOE-cadhLO could identify motile early-progressed tumor cells and predict for dissemination. We further show that mammary tissue macrophages and HER2HIp-ATF2LOE-cadhLO tumor cells cooperate to disseminate early.
- Medicine and Medical Research