Accession Number:

AD1033075

Title:

Early Detection of NSCLC Using Stromal Markers in Peripheral Blood

Descriptive Note:

Technical Report,01 Sep 2015,31 Aug 2016

Corporate Author:

Weill Cornell Medical College New York United States

Personal Author(s):

Report Date:

2016-09-01

Pagination or Media Count:

10.0

Abstract:

A recent screening trial showed that the use of low dose computed tomography LDCT resulted in a 20 reduction in lung cancer mortality, however there was a 96 false positive rate associated with LDCT. Thus, there is an immediate clinical need to develop a diagnostic biomarker that would select patients with CT detected nodules for further testing. The ease with which blood can be sampled makes it a logical choice in which to discover diagnostic biomarkers, however the clinical utility of tumor derived proteins, miRNA or circulating tumor cells as blood-based biomarkers has been limited. In this proposal, instead of tumor-derived biomarkers, we will focus on host response to tumor growth. It has been well documented that tumor growth systemically stimulates and mobilizes BM-derived hematopoietic cells to the tumor bed to establish a permissive microenvironment. Preliminary studies in our lab have shown that in lung cancer patients, the circulating myeloid cells are transcriptionally altered and the alteration is tumor dependent.

Subject Categories:

  • Medicine and Medical Research
  • Genetic Engineering and Molecular Biology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE