Treatment of Nueropathic Pain after SCI with a Catalytic Oxidoreductant
Technical Report,30 Sep 2015,29 Sep 2016
University of Alabama at Birmingham Birmingham United States
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The on-going research is to test the central hypothesis that post-SCI administration of the catalytic oxidoreductant BuOE will inhibit neuropathic pain after SCI. The research in years1-3 focused on the goals of aims 1-3, to test the hypothesis that post-SCI administration of BuOE decreases inflammation and ROS activation in a rat, mouse and porcine model of SCI. The main finding of our work in this year was to evaluate the dose-effect curve of post-SCI administration of BuOE on the outcomes listed above. Our data from on-going experiments indicate that the dose of 0.2mgkg BuOE was most effective in reducing inflammation and ROS activation acutely post-SCI in rats and mice. On-going experiments will evaluate additional outcome measures and behavioral outcomes in the subsequent year.
- Anatomy and Physiology