Targeting Signaling to YAP for the Therapy of NF2
Technical Report,30 Sep 2014,29 Sep 2016
Memorial Sloan-Kettering Institute for Cancer Research New York United States
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The goals of this project are to utilize our new knowledge of the mechanism by which loss of Merlin induces tumorigenesis to identify small molecule compounds that block YAPTEAD-dependent transcription by acting at any step of our newly identified pathway, and to test the preclinical efficacy of lead compounds in xenograft models of NF2. During this grant, we have generated NF2 mutant cell lines expressing two different types of YAP reporters and tested their suitability for high throughput screening.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research