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Optimizing Soft Tissue Management and Spacer Design in Segmental Bone Defects

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Technical Report,30 Sep 2013,29 Sep 2016

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Cleveland Clinic Foundation Cleveland United States

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This proposal addresses the treatment of segmental bone defects and methods that can be used to manipulate the Masquelet induced membrane to create a graft bed that optimizes bone regeneration. The effect of surgical management of the IM demonstrated a significant benefit of scraping to remove the inner layer of the IM p0.041. In contrast, modifying the texture on the PMMA spacer to double the surface area of the IM did not result in improved bone regeneration. This finding can be immediately translated into clinical practice. This study also highlights that the Chronic Caprine Tibial Defect Model is sufficiently sensitive to detect variations and represents a particularly well suitable relevant large animal model to advance the field of clinical bone regeneration using cellular therapies, and optimization of clinically relevant methods for harvest and processing of CTP sources to enhance the concentration and prevalence CTPs in the site of bone regeneration.

Subject Categories:

  • Medicine and Medical Research

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