Accession Number:

AD1031691

Title:

High Infection Rates in Adult Macaques Following Intravaginal or Intrarectal Zika Virus Inoculation

Descriptive Note:

Journal Article - Embargoed Full-Text

Corporate Author:

ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD FORT DETRICK United States

Report Date:

2017-04-07

Pagination or Media Count:

22.0

Abstract:

Unprotected sexual intercourse between persons residing in or traveling from regions with Zika virus transmission is a risk factor for infection. To model risk for infection after sexual intercourse, we inoculated rhesus and cynomolgus macaques with Zika virus by intravaginal or intrarectal routes. In macaques inoculated intravaginally, we detected viremia and virus RNA in 50 of macaques, followed by seroconversion. In macaques inoculated intrarectal, we detected viremia, virus RNA, or both, in 100 of both species, followed by seroconversion. The magnitude and duration of infectious virus in the blood of macaques suggest humans infected with Zika virus through sexual transmission will likely generate viremias sufficient to infect competent mosquito vectors. Our results indicate that transmission of Zika virus by sexual intercourse might serve as a virus maintenance mechanism in the absence of mosquito-to-human transmission and could increase the probability of establishment and spread of Zika virus in regions where this virus is not present.

Subject Categories:

  • Microbiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE