Genetic Modeling of Radiation Injury in Prostate Cancer Patients Treated with Radiotherapy
Technical Report,30 Sep 2015,29 Sep 2016
Albert Einstein College of Medicine of Yeshiva University Bronx United States
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From the completed analyses performed during the first year of the project, we have identified eleven SNPs that show an association with two-year toxicity following prostate cancer radiotherapy. Three of these single nucleotide polymorphisms SNPs meet the stringent threshold for genome-wide significance meta-p-value 5x10-8, and eight others approached genome-wide significance. For the three genome-wide significant SNPs, we found that the direction of the effect was consistent across all studies for which data were available.
- Medicine and Medical Research