Accession Number:

AD1031444

Title:

Genetic Modeling of Radiation Injury in Prostate Cancer Patients Treated with Radiotherapy

Descriptive Note:

Technical Report,30 Sep 2015,29 Sep 2016

Corporate Author:

Albert Einstein College of Medicine of Yeshiva University Bronx United States

Personal Author(s):

• Ostrer,Harry
• Rosenstein,Barry S.

Report Date:

2016-10-01

Pagination or Media Count:

14.0

Abstract:

From the completed analyses performed during the first year of the project, we have identified eleven SNPs that show an association with two-year toxicity following prostate cancer radiotherapy. Three of these single nucleotide polymorphisms SNPs meet the stringent threshold for genome-wide significance meta-p-value 5x10-8, and eight others approached genome-wide significance. For the three genome-wide significant SNPs, we found that the direction of the effect was consistent across all studies for which data were available.

Descriptors:

• prostate cancer
• radiotherapy
• statistical analysis
• neoplasms
• predictive modeling
• chemical reactions
• genetic markers
• physiological effects
• morbidity
• wounds and injuries
• nucleotides

Subject Categories:

• Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE