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Reinnervation of Paralyzed Muscle by Nerve Muscle Endplate Band Grafting

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Technical Report,15 Sep 2015,14 Sep 2016

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Hackensack University Medical Center Hackensack United States

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Our previous studies showed that NMEG-NMZ reinnervation technique resulted in functional recovery 82 of the control of the target muscle. In order to promote the efficacy of NME-NMZ, we investigated the effects of focal administration of exogenous neurotrophic factors ENF and intra-operative nerve electrical stimulation ES on the outcomes of NMEG-NMZ NN technique. At 3 months after treatment, we analyzed the muscle force, muscle mass, myofiber morphology, regenerated axons, and endplate reinnervation. The results showed that NNENF and NNES cotreatments resulted in more optimal functional recovery 91 and 90 of the control, respectively as compared with NMEG-NMZ surgery alone 82 . Histological and immunohistochemical studies showed that NNENF treated muscles exhibited excellent muscle mass recovery 92 of the control, abundant regenerated axons 84 of the control, and a high percentage 86 of reinnervated motor endplates. Our findings suggest that NNENF or NNES improves the outcomes of NMEG-NMZ reinnervation technique.

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  • Medicine and Medical Research

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