Candidate Medical Countermeasures Targeting Ebola Virus Cell Entry
USAMRIID Frederick United States
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Medical countermeasures against virus infections ideally prevent the adsorption or entry of virions into target cells, thereby circumventing infection. Recent significant advances in elucidating the mechanism of Ebola virus EBOV host-cell penetration include the involvement of two-pore channels at the early stage of entry, and identification of cellular proteases for EBOV spike glycoprotein maturation and the intracellular EBOV receptor, NPC1. This improved understanding of the initial steps of EBOV infection is now increasingly applied to rapid development of candidate medical countermeasures, some of which have already entered the clinic. In this review, we summarize the currently known spectrum of EBOV cell entry inhibitors, describe their mechanism of action, and their potential for future development.
- Medicine and Medical Research